As publicações resultantes dos trabalhos desenvolvidos pelos seus investigadores encontram-se listadas abaixo:
(última atualização julho 2024)
Analysis of Genes Involved in Oxidative Stress and Iron Metabolism in Heart Failure: A Step Forward in Risk Stratification, 2024. Silva PX, Aguiar L, Gaspar M, Faustino P, Falcão LM, Barbosa M, Bicho M, Inácio Â. Cureus. May 20;16(5):e60707. doi: 10.7759/cureus.60707. PMID: 38899268; PMCID: PMC11186693.
Antivirals (DAAs) on Liver Stiffness, Liver Fibrosis Stage and Metabolic/Cellular Parameters, Effects of HCV Clearance with Direct-Acting, 2024. Ferreira J, Bicho M, Serejo F. Viruses. 2024 Feb 27;16(3):371. doi: 10.3390/v16030371. PMID: 38543737; PMCID: PMC10974411.
The interplay between HPV, other Sexually Transmissible Infections and genital microbiome on cervical microenvironment (MicroCervixHPV study), 2024. Bicho M, Bicho MC. Front Cell Infect Microbiol. 2024 Mar 12;13:1251913. doi: 10.3389/fcimb.2023.1251913. PMID: 38532749; PMCID: PMC10963500.
Leiomyoma and the importance of genetic variation on genes related to the vasculature system – CβS, MTHFR, NOS3, CYBA, and ACE1, 2024. Inácio Â, Aguiar L, Rodrigues B, Pires P, Ferreira J, Bilhim T, Pisco J, Bicho M, Clara Bicho M. Eur J Obstet Gynecol Reprod Biol. 2024 Mar;294:65-70. doi: 10.1016/j.ejogrb.2024.01.009. Epub 2024 Jan 8. PMID: 38218160.
Genetic Contribution of the Adrenergic, Cholinergic, and Serotonergic Systems to Leiomyoma Development and Treatment, 2023. Inácio A, Aguiar L, Carrilho R, Pires P, Ferreira J, Coelho L, Mascarenhas MR, Sardinha L, Bilhim T, Pisco J, Bicho M, Bicho MC. Int J Mol Cell Med 2023; 12 (4) :320-334 URL: http://ijmcmed.org/article-1-1947-en.html
La importancia primordial de la disfunción renal en el pronóstico de la insuficiencia cardíaca- Resultados del estudio REFERENCE, 2023. Barbosa M, Matos A, Bicho M, Menezes Falcão L. Galicia Clínica, 84(2), 7. https://doi.org/10.22546/69/2726
Development and Implementation of a Nutritional Education Program Aimed at Improving the Integration Process of Young Orphan Refugees Newly Arrived in Portugal, 2023. Oliveira B, Bicho M, Valente A. Nutrients, 15(2). https://doi.org/10.3390/nu15020408
Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes, 2023. Inácio Â, Aguiar L, Rodrigues B, Pires P, Ferreira J, Matos A, … Bicho MC. Antioxidants, 12(10). https://doi.org/10.3390/antiox12101806
Sleep Patterns, Eating Behavior and the Risk of Noncommunicable Diseases, 2023. Gomes S, Ramalhete C, Ferreira I, Bicho, M, Valente, A. Nutrients, 15(11). https://doi.org/10.3390/nu15112462
Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity-A Multicenter Portuguese Cohort Study, 2023. Fevereiro-Martins M, Santos AC, Marques-Neves C, Guimarães H, Bicho M. International Journal of Molecular Sciences, 24(14). https://doi.org/10.3390/ijms241411817
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study, 2023. Fevereiro-Martins M, Santos AC, Marques-Neves C, Guimarães H, Bicho M. Graefe’s Archive for Clinical and Experimental Ophthalmology, 261(10), 2997–3006. https://doi.org/10.1007/s00417-023-06072-7
Retinopathy of prematurity: A review of pathophysiology and signaling pathways, 2023. Fevereiro-Martins M, Marques-Neves C, Guimarães H, Bicho M. Survey of Ophthalmology, 68(2), 175–210. https://doi.org/10.1016/j.survophthal.2022.11.007
Role of Inflammatory/Immune Response and Cytokine Polymorphisms in the Severity of Chronic Hepatitis C (CHC) before and after Direct Acting Antiviral (DAAs) Treatment, 2023. Ferreira J, Oliveira M, Bicho M, Serejo F. International Journal of Molecular Sciences, 24(2). https://doi.org/10.3390/IJMS24021380
Influence of the TAS2R38 Gene Single Nucleotide Polymorphisms in Metabolism and Anthropometry in Thyroid Dysfunction, 2023. Costa MM, Silva AP, Santos C, Ferreira J, Mascarenhas MR, Bicho M, Barbosa A P. Nutrients, 15(9). https://doi.org/10.3390/NU15092214
Angiotensin-Converting Enzyme Activity May Predict Disease Severity in Psoriasis, 2022. Bandeira M, Gil Â, Santos AC, Romão VC, Mascarenhas MR, Filipe P, … Bicho M. Rheumato, 2(1), 15–23. https://doi.org/10.3390/rheumato2010003
Neglected hematological parameters in heart failure prognosis – Disclosures from the REFERENCE study, 2022. Barbosa M, Matos A, Bicho M, Falcao LM. Galicia Clinica, 83(2), 20–31. https://doi.org/10.22546/65/2413
Contribution of HFE and HPSE genes and methaemoglobin reductase activity to heart failure, 2022. Gaspar M, Aguiar L, Ferreira J, Faustino P, Mascarenhas MR, Falcao LM, Bicho M, Inacio, A. Medicine, 101(30).
Retinopathy of prematurity: contribution of inflammatory and genetic factors. Molecular and Cellular Biochemistry, 2022. Fevereiro-Martins M, Guimarães H, Marques-Neves C, Bicho M, 477(6), 1739–1763. https://doi.org/10.1007/s11010-022-04394-4
Hepatitis C Is Gender-Specific and Modulates Liver Disease Severity through Its Influence on Cholesterol Metabolism and Liver Function: A Preliminary Study, 2022. Ferreira J, Bicho M, Serejo F. ABCA1 Polymorphism R1587K in Chronic Genes, 13(11). https://doi.org/10.3390/genes13112095
Exposure to heavy metals and red blood cell parameters in children: A systematic review of observational studies, 2022. Capitão C, Martins R, Santos O, Bicho M, Szigeti T, Katsonouri A., … Virgolino A. Frontiers in Pediatrics, 10, 921239. https://doi.org/10.3389/fped.2022.921239
Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression, 2021. Matos A, Carvalho M, Bicho M, Ribeiro R Nutrients. Dec 16;13(12):4503. doi: 10.3390/nu13124503. PMID: 34960055; PMCID: PMC8704013.
Differences in the genotype frequencies of genes related to blood pressure regulation – a comparative study between South-West Europe and Peri-equatorial Africa, 2021. Aguiar L, Semente I, Ferreira J, Carvalho A, Pereira A, Carroça C, Caria H, Damasceno A, Laires MJ, Sardinha L, Monteiro C, Mascarenhas MR, Faustino P, Inácio A, Bicho M, 2021. African Health Sciences.;21(4):1669-76, https://dx.doi.org/10.4314/ahs.v21i4.21
The Importance of the Extracellular Matrix in HPV-Associated Diseases, 2021. Sampaio J, Ferreira J, Santos AC, Bicho M, Bicho MC. DOI: 10.5772/intechopen.99907
Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms with hypertensive disorders in women. da Silva IV, Santos AC, Matos A, Pereira da Silva A, Soveral G, Rebelo I, Bicho M, 2021. Pregnancy Hypertens. Jun;24:44-49. doi: 10.1016/j.preghy.2021.02.008.
Interplay between glycemia and the genetics of eNOS and ACE for the susceptibility to the onset and development of hypertension on the Portuguese population. Aguiar L, Ferreira J, Matos A, Mascarenhas R, Falcão LM, Faustino P, Bicho M, Inácio A, 2021. Gene Reports, Volume 22, doi.org/10.1016/j.genrep.2020.100975.
Renin Angiotensin System, Gut-Lung Cross Talk and Microbiota. Lessons from SARS-CoV Infections. Matos A, Silva AP, Ferreira J, Santos AC, Bicho MC, Bicho M, 2021. DOI: 10.5772/intechopen.94325
Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: a secondary analysis from a 1-year randomized controlled trial. Magalhães JP, Santos DA, R Correia I, Hetherington-Rauth M, Ribeiro R, F Raposo J, Matos A, D Bicho M, B Sardinha L, 2020. Cardiovascular Diabetology, 7;19(1):169. doi: 10.1186/s12933-020-01136-y.
Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption, Oxidative Medicine and Cellular Longevity. Pereira da Silva A, Costa MC, Aguiar L, Matos A, Gil Â, Gorjão-Clara J., 2020. 30;2020:1305413. doi: 10.1155/2020/1305413.
Endothelial dysfunction in asthma: eNOS, iNOS and ACE polymorphisms. Castro MC, Ferreira J, Matos A, Bicho M., 2020. ERJ Open Research 6 (suppl 5)
Towards a Global Perspective of Environmental Health: Defining the Research Grounds of an Institute of Environmental Health. Virgolino A, Antunes F, Santos O, Costa A, Gaspar de Matos M, Bárbara C, Bicho M, Caneiras C, Sabino R, Núncio MS, Matos O, Santos RR, Costa J, Alarcão V, Gaspar T, Ferreira J, Vaz Carneiro A., 2020. Sustainability 12 (21): 8963; doi.org/10.3390/su12218963.
The Possible Influence of Microbiota on Food Compulsion. Arantes R, Alves E, Bicho M, Valente A., 2020.Open Acc J Bio Sci. June – 2(2): 353-358.
Nutritional Status and Sugary Drinks Consumption in Children from 6 to 9 years. Santos T, Bicho M, Valente A., 2020. Open Acc J Bio Sci. March – 1(6): 234-240.
Polimorfismos genéticos e a sua interação na suscetibilidade para a hipertensão na população portuguesa. Aguiar L, Semente I, Ferreira J, Matos A, Mascarenhas MR, Menezes Falcão L, Faustino P, Bicho M, Inácio Â., 2020. Revista Portuguesa de Hipertensão e Risco Cardiovascular 2020; 76:12-16.
Hepatitis C Pretreatment Profile and Gender Differences: Cognition and Disease Severity Effects Barreira DP, Marinho RT, Bicho M, Flores I, Fialho R, Ouakinin S., 2019. Front Psychol. 2019 15;10:2317. doi: 10.3389/fpsyg.2019.02317.
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes: a 1-year randomized controlled trial. Magalhães JP, Melo X, Correia IR, Ribeiro RT, Raposo J, Dores H, Bicho M, Sardinha LB, 2019. Cardiovasc Diabetol. 2019 Mar 18;18(1):34. doi: 10.1186/s12933-019-0840-2.
Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children. Aguiar L, Marinho C, Martins R, Alho I, Ferreira J, Levy P, Faustino P, Bicho M, Inácio A., 2019. Cell Mol Biol (Noisy-le-grand). 2019 Feb 28;65(2):69-74.
Psychosocial and Neurocognitive Factors Associated With Hepatitis C – Implications for Future Health and Wellbeing. Barreira DP, Marinho RT, Bicho M, Fialho R, Ouakinin SRS., 2019. Front Psychol. 9;9:2666. doi: 10.3389/fpsyg.2018.02666.
Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase. Pereira da Silva A, Matos A, Aguiar L, Ramos-Marques N, Ribeiro R, Gil Â, Gorjão-Clara J, Bicho M., 2019. Mol Cell Biochem. May;455(1-2):61-71. doi: 10.1007/s11010-018-3470-1.
Effectiveness of high-intensity interval training combined with resistance training versus continuous moderate-intensity training combined with resistance training in patients with type 2 diabetes: A one-year randomized controlled trial. Magalhães JP, Júdice PB, Ribeiro R, Andrade R, Raposo J, Dores H, Bicho M, Sardinha LB., 2019. Diabetes Obes Metab. Mar;21(3):550-559. doi: 10.1111/dom.13551.
High SLC7A11 expression in normal skin of melanoma patients. Galván I, Inácio A, Dañino M, Corbí-Llopis R, Monserrat MT, Bernabeu-Wittel J., 2019. Cancer Epidemiol.Aug 13, 62, 101582.
Changes in melanocyte RNA and DNA methylation favor pheomelanin synthesis and may avoid systemic oxidative stress after dietary cysteine supplementation in birds. Rodríguez-Martínez S, Márquez R, Inácio A, Galván I, 2019. Mol Ecol. 28, 5, 1030-1042.
Body composition and different criteria for obesity evaluation in type 2 diabetic patients with and without angiopathy. Valente A, Bicho M, Duarte R, Raposo JF., 2019. Open Acc J Bio Sci. 1, 2, 47-56.
Efeito da toma de citrulina, um precursor da arginina sobre as atividades de enzimas eritrocitárias em ratos. Inácio A, Aguiar L, Gil A, Bicho M, 2019. Boletim da Sociedade Portuguesa de Hemorreologia e Microcirculação. Vol 34, nº 1, 5-9.
The metabolic impact of glutathione-s-transferases polymorphisms in the susceptibility for reduced bone mass. Bicho M, Ferreira J, Carvalho C, Ribeiro C, Sarmento D, Barbosa AP, Mascarenhas MR., 2019. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo. 14, 37-38.
Mulheres na pré-menopausa com hipertiroidismo têm pior qualidade óssea e mais fraturas vertebrais silenciosas. Barbosa AP, Fortes I, Mascarenhas MR, Pereira Dias R, Santos F, Bicho M, 2019. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo. 14, 38-39.
Genetics of renin-angiotensin pathway on metabolic parameters and on the severity of liver disease in HCV patients. Bicho M, Ferreira J, Ribeiro C, Carvalho C, Sarmento D, Serejo F, 2019 Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo. 14, 52-53.
Atividade enzimática do ECA e seu polimorfismo I/D podem influenciar o metabolismo muscular numa ultramaratona. Alonso I, Matos A, Gil A, Santos AC, Ribeiro R, Cardoso C, Bicho M., 2019. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo. 14, 99-100.
Avaliação da relação da ingestão alimentar com a microbiota intestinal em atletas de endurance. Rodrigues F, Mendonça R, Matos A, Costa e Silva L, Valentim O, Cardoso C, Bicho, M, Alonso I., 2019. Revista Portuguesa de Cirurgia. Novembro 2019, 57.
Contribuição para a intervenção na obesidade com diferentes tipos de abordagens de cirurgia bariátrica no Hospital St. Louis. Albuquerque A, Lopez-Nava G, Matos A, Cardoso C, Bicho M, Alonso I., 2019. Revista Portuguesa de Cirurgia. Novembro 2019, 54.
Avaliação da ingestão nutricional, composição corporal e biomarcadores do sistema redox em atletas de endurance no início de uma época de competição. Amaro R, Mendonça R, Matos A, Costa e Silva L, Valentim O, Cardoso C, Bicho, M, Alonso I., 2019. Revista Portuguesa de Cirurgia. Novembro 2019, 56.
Genetic predisposition for essential hypertension, based on studies of genetic polymorphisms in modern global human populations: The perspective of evolutionary biology. Bicho M. Rev Port Cardiol. 2018 Jun; 37 (6): 509‐510.
Characterization of Portuguese Centenarian Eating Habits, Nutritional Biomarkers, and Cardiovascular Risk: A Case Control Study. da Silva AP, Valente A, Chaves C, Matos A, Gil A, Santos AC, Gorjão‐Clara JP, Bicho M. Oxid Med Cell Longev. 2018 Mar 13; 2018: 5296168.
Genital mycoplasmas and ureaplasmas in cervicovaginal self-collected samples of reproductive-age women: prevalence and risk factors. Silva J, Cerqueira F, Teixeira AL, Bicho MC, Campainha R, Amorim J, Medeiros R Int J STD AIDS. 2018 Sep 29, 10, 999-1006.
Total Knockdown of LMW‐PTP in MDA‐MB‐231 Cells Reduces Osteoclastogenesis. Sapinho G, Alho I, Bicho M, Coelho C. Anticancer Res. 2017 Dec; 37 (12): 6671‐6677. Mountain Cycling Ultramarathon Effects on Inflammatory and Hemoglobin Responses. Alonso I, Matos A, Ribeiro R, Gil Â, Cardoso C, Sardinha LB, Bicho M. Med Sci Sports Exerc. 2018 Feb; 50 (2): 353‐360.
The main autoimmune and nonautoimmune etiologies of endogenous hyperthyroidism do not seem to influence the increased prevalence of morphometric vertebral fractures and osteoporosis in Portuguese men. Barbosa AP, Mascarenhas MR, Bicho M, Janeiro J, Oliveira AG. Osteoporos Sarcopenia. 2017 Sep; 3(3): 149‐154.
Is there a genetic support for the Cloninger (type I/II) clinical classification of alcohol addiction? Pombo S, Ferreira J, Levy PQ, Bicho M. Psychiatry Res. 2017 Dec; 258: 621‐623.
Coordination between antioxidant defenses might be partially modulated by magnesium status. Monteiro CP, Matias CN, Bicho M, Santa‐Clara H, Laires MJ. Magnes Res. 2016 Apr 1; 29 (4): 161‐168.
Sickle cell anemia ‐ Nitric oxide related genetic modifiers of hematological and biochemical parameters. Aguiar L, Matos A, Gil Â, Afonso C, Almeida S, Braga L, Lavinha J, Kjollerstrom P, Faustino P, Bicho M, Inácio Â. Clin Hemorheol Microcirc. 2016; 64 (4): 957‐963.
Hormonal modulation of novelty processing in women: Enhanced under working memory load with high dehydroepiandrosterone‐sulfate‐to‐dehydroepiandrosterone ratios. do Vale S, Selinger L, Martins JM, Bicho M, do Carmo I, Escera C. Neurosci Lett. 2016 Nov 10; 634: 98‐103.
Sarcopenia and osteoporosis in portuguese centenarians. da Silva AP, Matos A, Ribeiro R, Gil Â, Valente A, Bicho M, Gorjão‐Clara J. Eur J Clin Nutr. 2017 Jan; 71 (1): 56‐63.
Mechanisms underlying the association between obesity and Hodgkin lymphoma. Matos A, Marinho‐Dias J, Ramalheira S, Oliveira MJ, Bicho M, Ribeiro R. Tumor Biol. 2016 Oct; 37 (10): 13005‐13016.
Low Molecular Weight Protein Tyrosine Phosphatase Slow Isoform Knockdown in MDA‐MB‐ 435 Cells Decreases RAW 264.7 Osteoclastic Differentiation. Alho I, Costa L, Bicho M, Coelho C. Anticancer Res. 2016 May; 36 (5): 2227‐32.
Body Composition Assessment and Nutritional Status Evaluation in Men and Women Portuguese Centenarians. Pereira da Silva A, Matos A, Valente A, Gil Â, Alonso I, Ribeiro R, Bicho M, Gorjão‐Clara J. J Nutr Health Aging. 2016 Mar;20(3):256‐66.
Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer. Matos A, Castelão C, Pereira da Silva A, Alho I, Bicho M, Medeiros R, Bicho MC. Oxid Med Cell Longev. 2016; 2016: 2769804.
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone‐sulfate (DHEAS) and emotional processing ‐ A behavioral and electrophysiological approach. do Vale S, Selinger L, Martins JM, Bicho M, do Carmo I, Escera C. Horm Behav. 2015 Jul; 73: 94‐103.
Association of myeloperoxidase polymorphism (G463A) with cervix cancer. Castelão C, da Silva AP, Matos A, Inácio Â, Bicho M, Medeiros R, Bicho MC. Mol Cell Biochem. 2015 Jun; 404 (1‐2): 1‐4.
Prevalence of silent vertebral fractures detected by vertebral fracture assessment in young Portuguese men with hyperthyroidism. Barbosa AP, Rui Mascarenhas M, Silva CF, Távora I, Bicho M, do Carmo I, de Oliveira AG. Eur J Endocrinol. 2015 Feb; 172 (2): 189‐94.
The role of CYBA (p22phox) and catalase genetic polymorphisms and their possible epistatic interaction in cervical cancer. Castaldo SA, da Silva AP, Matos A, Inácio Â, Bicho M, Medeiros R, Alho I, Bicho MC. Tumor Biol. 2015 Feb; 36 (2): 909‐14.
The relationship between dehydroepiandrosterone (DHEA), working memory and distraction‐‐ a behavioral and electrophysiological approach. do Vale S, Selinger L, Martins JM, Gomes AC, Bicho M, do Carmo I, Escera C. PLoS One. 2014 Aug 8; 9 (8): e104869.
In women with previous pregnancy hypertension, levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism. Matos A, Pereira da Silva A, Clara Bicho M, Afonso C, Areias MJ, Rebelo I, Bicho M. Obstet Gynecol Int. 2014; 2014: 361727.
The role of 5‐HTTLPR polymorphism in alcohol craving experience. Pombo S, Ferreira J, Cardoso JM, Ismail F, Levy P, Bicho M. Psychiatry Res. 2014 Aug 15; 218 (1‐2): 174‐9.
Anticancer activity of structurally related ruthenium (II) cyclopentadienyl complexes. Côrte‐Real L, Mendes F, Coimbra J, Morais TS, Tomaz AI, Valente A, Garcia MH, Santos I, Bicho M, Marques F. J Biol Inorg Chem. 2014 Aug; 19 (6): 853‐67.